Title : Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism.

Pub. Date : 1993 Oct 15

PMID : 8408019






5 Functional Relationships(s)
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Protein Name
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1 Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism. Folic Acid folylpolyglutamate synthase Homo sapiens
2 Essentially all transported folate was metabolized to retained polyglutamate derivatives, the chain length of which varied with the level of FPGS activity. Folic Acid folylpolyglutamate synthase Homo sapiens
3 As medium folate concentration increased through the physiological to the pharmacological range, cellular folate accumulation became proportional to FPGS activity and the chain length of intracellular folates decreased. Folic Acid folylpolyglutamate synthase Homo sapiens
4 As medium folate concentration increased through the physiological to the pharmacological range, cellular folate accumulation became proportional to FPGS activity and the chain length of intracellular folates decreased. Folic Acid folylpolyglutamate synthase Homo sapiens
5 At high folate concentrations, competition between substrates for FPGS limited the extent of polyglutamylation and less than 5% of transported folate was retained by the cell. Folic Acid folylpolyglutamate synthase Homo sapiens