Pub. Date : 1993 Jun
PMID : 8396619
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Perifused equine anterior pituitary cells were used to investigate the effect of cortisol on the ACTH response to pulses of corticotrophin-releasing hormone (CRH; 0.01 nmol/l) and arginine vasopressin (AVP; 100 nmol/l), given for 5 min every 30 min for 690 min and ACTH measured in 5-min fractions. | Hydrocortisone | pro-opiomelanocortin | Equus caballus |
| 2 | Analysis of variance of the data showed that the higher the cortisol concentration, the quicker the ACTH response area (P = 0.0072) and peak height (P = 0.002) decreased to < 50% of mean control, and the greater the maximum percentage change (suppression) in ACTH response area (P < 0.0001) and peak height (P < 0.0001). | Hydrocortisone | pro-opiomelanocortin | Equus caballus |
| 3 | Analysis of variance of the data showed that the higher the cortisol concentration, the quicker the ACTH response area (P = 0.0072) and peak height (P = 0.002) decreased to < 50% of mean control, and the greater the maximum percentage change (suppression) in ACTH response area (P < 0.0001) and peak height (P < 0.0001). | Hydrocortisone | pro-opiomelanocortin | Equus caballus |
| 4 | At +30 min after the start of cortisol perifusion, the ACTH response area in CRH columns was significantly lower than in AVP columns (P = 0.0088), and remained lower 90 min after the end of perifusion (P = 0.0084) but the maximum percentage change (suppression) was not different between secretagogues. | Hydrocortisone | pro-opiomelanocortin | Equus caballus |