Pub. Date : 1993 Sep
PMID : 8395533
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-3 inhibits cycloheximide induction of C-jun mRNA in human monocytes: possible role for a serine/threonine phosphatase. | Cycloheximide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Cycloheximide is a strong inducer of the c-jun protooncogene mRNA at concentrations (< or = 50 ng/ml) that do not inhibit protein synthesis in human monocytes. | Cycloheximide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | The pluripotent colony stimulating factor interleukin-3 (IL-3) (10 ng/ml) is also a modest inducer of the c-jun gene in these cells; however, in combination with cycloheximide, IL-3 dramatically reduces the c-jun induction below levels induced by cycloheximide alone. | Cycloheximide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 4 | Preincubation of monocytes with 12.5 nM okadaic acid (a potent inhibitor of protein phosphatases 1 and 2A) and cycloheximide prior to addition of IL-3 restored the level of c-jun induction to that mediated by cycloheximide alone. | Cycloheximide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 5 | Preincubation of monocytes with 12.5 nM okadaic acid (a potent inhibitor of protein phosphatases 1 and 2A) and cycloheximide prior to addition of IL-3 restored the level of c-jun induction to that mediated by cycloheximide alone. | Cycloheximide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 6 | These observations suggest that activation of protein serine/threonine phosphatase(s) underlies the ability of IL-3 to inhibit cycloheximide induction of c-jun in monocytes. | Cycloheximide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |