Title : WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity.

Pub. Date : 1993 May 19

PMID : 8391458






2 Functional Relationships(s)
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1 WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity. Tromethamine arachidonate 5-lipoxygenase Rattus norvegicus
2 WY-50,295 tromethamine demonstrates significant 5-lipoxygenase inhibitory activity with IC50 values ranging from 0.055 microM in rat peritoneal exudate cells, to 0.16 microM in mouse macrophages, 1.2 microM in human peripheral neutrophils and 8.1 microM in rat blood leukocytes. Tromethamine arachidonate 5-lipoxygenase Rattus norvegicus