Pub. Date : 1993 Jun
PMID : 8390491
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protein-bound tyrosyl residues exposed to myeloperoxidase, H2O2, and L-tyrosine were oxidized to o,o"-dityrosine, a stable product of the tyrosyl radical. | dityrosine | myeloperoxidase | Homo sapiens |
| 2 | The requirement for free L-tyrosine and H2O2 for dityrosine formation and the inhibition by heme poisons support the hypothesis that myeloperoxidase catalyzes the cross-linking of proteins by a peroxidative mechanism involving tyrosyl radical. | dityrosine | myeloperoxidase | Homo sapiens |
| 3 | We speculate that protein dityrosine cross-linking by myeloperoxidase may play a role in bacterial killing or injuring normal tissue. | dityrosine | myeloperoxidase | Homo sapiens |
| 4 | The intense fluorescence and stability of biphenolic compounds may allow dityrosine to act as a marker for proteins oxidatively damaged by myeloperoxidase in phagocyte-rich inflammatory lesions. | dityrosine | myeloperoxidase | Homo sapiens |