Title : Coexpression of erythropoietin and heme oxygenase genes in Hep3B cells.

Pub. Date : 1993 May

PMID : 8387947






3 Functional Relationships(s)
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Protein Name
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1 Exposure of Hep3B cells to metalloporphyrins (tinprotoporphyrin and heme) or cobalt chloride resulted in the production of a significant number of heme oxygenase transcripts, erythropoietin transcripts or both, as indicated by in situ hybridization. tin protoporphyrin IX erythropoietin Homo sapiens
2 Tin-protoporphyrin (10 mumol/L) produced an eightfold to 10-fold increase in erythropoietin RNA within 40 min. tin protoporphyrin IX erythropoietin Homo sapiens
3 Thus both erythropoietin and heme oxygenase genes appear to be expressed after treatment with tin-protoporphyrin, heme or cobalt chloride; however, the time and patterns of expression are different. tin protoporphyrin IX erythropoietin Homo sapiens