Title : Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies.

Pub. Date : 1993 Apr

PMID : 8386241






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Covalent binding required oxygen and NADPH, and was decreased by the nucleophile glutathione and by the cytochrome P-450 inhibitors SKF 525-A, piperonyl butoxide and troleandomycin (an inhibitor of the cytochrome P-450 3A subfamily). Oxygen cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Covalent binding required oxygen and NADPH, and was decreased by the nucleophile glutathione and by the cytochrome P-450 inhibitors SKF 525-A, piperonyl butoxide and troleandomycin (an inhibitor of the cytochrome P-450 3A subfamily). Oxygen cytochrome P450 family 4 subfamily F member 3 Homo sapiens