Title : SDZ 216-525, a selective and potent 5-HT1A receptor antagonist.

Pub. Date : 1993 Feb 15

PMID : 8384569






1 Functional Relationships(s)
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1 SDZ 216-525 potently antagonised the effects of 8-OH-DPAT (8-hydroxy-2-[N-dipropyl-amino]-tetralin) on 5-HT1A receptors (pKB = 10) and displayed no intrinsic activity in this test, whereas it behaved at best as a weak antagonist on the other receptor models (pKB values < 6.9). 8-Hydroxy-2-(di-n-propylamino)tetralin 5-hydroxytryptamine receptor 1A Bos taurus