Title : Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro.

Pub. Date : 1993 Feb

PMID : 8383401






2 Functional Relationships(s)
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1 Both lidocaine and bupivacaine inhibited the release of the inflammatory mediators leukotriene B4 (LTB4) and interleukin-1 (IL-1) evaluated by radioimmunoassay (RIA). Lidocaine interleukin 1 alpha Homo sapiens
2 In short-term (24 h) cultures of mononuclear cells the addition of lidocaine or bupivacaine reduced, in a dose-dependent manner, the level of IL-1 detected after stimulation with lipopolysaccharide (LPS). Lidocaine interleukin 1 alpha Homo sapiens