Title : Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells.

Pub. Date : 1993 Jan

PMID : 8381608






2 Functional Relationships(s)
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1 Exposure to 6-25 dyn/cm2 for > or = 6 h dramatically inhibited ET-1 release and led to 0-70% inhibition of cumulative release by 16 h. Pretreatment with N omega-nitro-L-arginine (L-NNA) reversed this suppression in a dose-dependent manner, implicating either nitric oxide (NO) and/or guanosine 3",5"-cyclic monophosphate (cGMP) as a requirement for shear-mediated inhibition of ET-1 release. Nitroarginine endothelin 1 Homo sapiens
2 Exposure to 6-25 dyn/cm2 for > or = 6 h dramatically inhibited ET-1 release and led to 0-70% inhibition of cumulative release by 16 h. Pretreatment with N omega-nitro-L-arginine (L-NNA) reversed this suppression in a dose-dependent manner, implicating either nitric oxide (NO) and/or guanosine 3",5"-cyclic monophosphate (cGMP) as a requirement for shear-mediated inhibition of ET-1 release. Nitroarginine endothelin 1 Homo sapiens