Title : Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells.

Pub. Date : 1993 Jan

PMID : 8381319






3 Functional Relationships(s)
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1 Incubation of GTN (150-1200fJM) for 30min with NAC (0.1-1mM) led to aconcentration-dependent increase in N02- formation. Nitroglycerin synuclein alpha Homo sapiens
2 The reduced ability of tolerant SMC or EC to potentiate the anti-platelet activity of GTN was restored by NAC (0.5 mM). Nitroglycerin synuclein alpha Homo sapiens
3 NAC, by directly forming NO from GTN, compensates for this failing mechanism. Nitroglycerin synuclein alpha Homo sapiens