Title : Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells.

Pub. Date : 1993 Jan

PMID : 8381319






2 Functional Relationships(s)
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1 Exposure of non-tolerant SMC or EC (10(5) cells) to GTN (200 microM) for 3 min increased (3-4 fold) the levels of guanosine 3":5"-cyclic monophosphate (cyclic GMP). Nitroglycerin 5'-nucleotidase, cytosolic II Homo sapiens
2 Furthermore, when compared to normal cells, tolerant SMC or EC metabolize GTN to NO less effectively as assessed by the reduced capacity to potentiate the antiplatelet effects of GTN, to release NO2- and to increase the level of cyclic GMP. Nitroglycerin 5'-nucleotidase, cytosolic II Homo sapiens