Title : Protection by antibiotics against myeloperoxidase-dependent cytotoxicity to lung epithelial cells in vitro.

Pub. Date : 1993 Jan

PMID : 8380814






2 Functional Relationships(s)
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1 These results suggest that aminoglycosides protect lung epithelial cells against myeloperoxidase-dependent oxidant injury by binding to anionic cell surfaces and converting HOCl to hydrophilic noncytotoxic chloramines, whereas penicillins and cephalosporins are potent HOCl scavengers capable of protecting critical extracellular molecules against oxidation. Hypochlorous Acid myeloperoxidase Homo sapiens
2 These results suggest that aminoglycosides protect lung epithelial cells against myeloperoxidase-dependent oxidant injury by binding to anionic cell surfaces and converting HOCl to hydrophilic noncytotoxic chloramines, whereas penicillins and cephalosporins are potent HOCl scavengers capable of protecting critical extracellular molecules against oxidation. Hypochlorous Acid myeloperoxidase Homo sapiens