Title : Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells.

Pub. Date : 1993 Sep 25

PMID : 8376401






2 Functional Relationships(s)
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1 This effect was blocked by inhibitors of protein synthesis, suggesting that butyrate causes the induction of an activity that has a negative effect on c-myc expression. Butyrates MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 In the present work we demonstrate that the rapid decrease in the level of c-myc RNA, upon treatment of SW837 cells with 2 mM butyrate, is followed by a slower decrease in the level of p53 RNA and an increase in the RNA levels for fibronectin and a placental type alkaline phosphatase. Butyrates MYC proto-oncogene, bHLH transcription factor Homo sapiens