Pub. Date : 1993 Jul
PMID : 8373725
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-1 selectively potentiates bradykinin-stimulated arachidonic acid release from human synovial fibroblasts. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 2 | Exposure of human synovial fibroblasts prelabelled with [3H]arachidonic acid to bradykinin causes a rapid and sustained increase in arachidonic acid release, a transient increase in cytosolic calcium and an increase in radiolabelled diacylglycerol. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 3 | Activation of arachidonic acid release by bradykinin was potentiated by interleukin-1 added either simultaneously with bradykinin or to cultures 24 h before addition of bradykinin. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 4 | Activation of arachidonic acid release by bradykinin was potentiated by interleukin-1 added either simultaneously with bradykinin or to cultures 24 h before addition of bradykinin. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 5 | Activation of arachidonic acid release by bradykinin was potentiated by interleukin-1 added either simultaneously with bradykinin or to cultures 24 h before addition of bradykinin. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 6 | The stimulation of arachidonic acid release in response to bradykinin, in the absence or presence of interleukin-1, was not affected by RHC-80267, an inhibitor of diacylglycerol kinase, suggesting that deacylation of diacylglycerol was not an important pathway of arachidonic acid production in cultures exposed to bradykinin. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 7 | The stimulation of arachidonic acid release in response to bradykinin, in the absence or presence of interleukin-1, was not affected by RHC-80267, an inhibitor of diacylglycerol kinase, suggesting that deacylation of diacylglycerol was not an important pathway of arachidonic acid production in cultures exposed to bradykinin. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 8 | The stimulation of arachidonic acid release in response to bradykinin, in the absence or presence of interleukin-1, was not affected by RHC-80267, an inhibitor of diacylglycerol kinase, suggesting that deacylation of diacylglycerol was not an important pathway of arachidonic acid production in cultures exposed to bradykinin. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 9 | Bradykinin-stimulated release of arachidonic acid was prevented by down-regulating protein kinase C by pretreatment with phorbol 12-myristate 13-acetate and was unaffected by inhibitors of protein synthesis actinomycin D or cycloheximide. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 10 | On the other hand, interleukin-1 amplification of bradykinin-stimulated release of arachidonic acid was blocked by actinomycin D and cycloheximide. | Arachidonic Acid | kininogen 1 | Homo sapiens |
| 11 | The results from this study point to activation of phospholipase A2 as the source of arachidonic acid in response to bradykinin. | Arachidonic Acid | kininogen 1 | Homo sapiens |