Title : Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse.

Pub. Date : 1993 Sep 1

PMID : 8373445






1 Functional Relationships(s)
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1 Phenacetin, a fairly specific CYP1A2 inhibitor, caused concentration-dependent competitive inhibition of MTR O-dealkylation (ki approximately 20 microM at 0.5 microM substrate) in hepatic microsomes from 3,4,5,3",4",5"-hexachlorobiphenyl-treated rats. Phenacetin cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus