Title : Thrombospondin (TSP1) mediates in vitro proliferation of human MG-63 osteoblastic cells induced by alpha-thrombin.

Pub. Date : 1993 Aug 30

PMID : 8365478






2 Functional Relationships(s)
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1 Proliferation of osteoblastic cells induced by alpha-thrombin or TSP was specifically and totally inhibited by anti-TSP monoclonal antibodies (3-10 micrograms/ml) or by indomethacin (1 microM), an inhibitor of prostaglandin synthesis. Prostaglandins coagulation factor II, thrombin Homo sapiens
2 Our experiments support the existence of a mechanism whereby TSP bound to the cell surface of thrombin-treated MG-63 cells stimulates secretion of prostaglandins which, in turn, allow cell proliferation to proceed. Prostaglandins coagulation factor II, thrombin Homo sapiens