Pub. Date : 1993
PMID : 8352882
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The goal of this study was to compare the response of mouse epidermal keratinocytes (MEKs) and human epidermal keratinocytes (HEKs) to 12-O-tetradecanoylphorbol-13-acetate (TPA) with respect to the activation and downregulation of protein kinase C (PKC), the expression of c-jun and c-fos, and the expression and induction of ornithine decarboxylase (ODC) activity. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 2 | Activation of partially purified total PKC by TPA was similar in freshly isolated and cultured MEKs and HEKs, indicating that the two species were similar in this regard and that 2 wk of culture did not alter this characteristic. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 3 | When MEK and HEK cultures were treated with TPA for 3 h, less than 30% of the control level of PKC activity was detected, indicating that TPA-induced downregulation of PKC was similar in MEKs and HEKs. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 4 | When MEK and HEK cultures were treated with TPA for 3 h, less than 30% of the control level of PKC activity was detected, indicating that TPA-induced downregulation of PKC was similar in MEKs and HEKs. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |