Title : Tumor necrosis factor-alpha inhibits endothelium-dependent relaxation.

Pub. Date : 1993 May

PMID : 8335573






2 Functional Relationships(s)
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1 TNF-alpha (0.00417, 0.0417, 0.417, and 1.25 micrograms/ml) incubated with BPA for 60 min inhibited EDR of the BPA to ACh, BK, and histamine. Histamine tumor necrosis factor Homo sapiens
2 The effect of TNF-alpha was specific for release of NO from the endothelium of BPA because TNF-alpha did not affect 1) EDR of BPV to ACh, BK, or ATP; 2) EIR of BPA or BPV to nitroprusside; and 3) contraction of either BPA or BPV to KCl, U-46619, histamine, norepinephrine, or serotonin. Histamine tumor necrosis factor Homo sapiens