Title : The enteric nervous system modulates mammalian duodenal mucosal bicarbonate secretion.

Pub. Date : 1993 Aug

PMID : 8335196






5 Functional Relationships(s)
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1 VIP-stimulated bicarbonate secretion was significantly inhibited by TTX (-73%), yet Isc and PD remained unchanged. Bicarbonates vasoactive intestinal peptide Homo sapiens
2 Atropine decreased VIP-induced bicarbonate secretion (-69%) and Isc (-43%). Bicarbonates vasoactive intestinal peptide Homo sapiens
3 CONCLUSIONS: These results suggest that (1) enteric nerve stimulation activates an acetylcholine receptor that in turn stimulates duodenal epithelial bicarbonate secretion; (2) VIP stimulates bicarbonate secretion, in large part, via the enteric nervous system; and (3) PGE2 and cAMP stimulate bicarbonate secretion independent of the enteric nervous system. Bicarbonates vasoactive intestinal peptide Homo sapiens
4 CONCLUSIONS: These results suggest that (1) enteric nerve stimulation activates an acetylcholine receptor that in turn stimulates duodenal epithelial bicarbonate secretion; (2) VIP stimulates bicarbonate secretion, in large part, via the enteric nervous system; and (3) PGE2 and cAMP stimulate bicarbonate secretion independent of the enteric nervous system. Bicarbonates vasoactive intestinal peptide Homo sapiens
5 CONCLUSIONS: These results suggest that (1) enteric nerve stimulation activates an acetylcholine receptor that in turn stimulates duodenal epithelial bicarbonate secretion; (2) VIP stimulates bicarbonate secretion, in large part, via the enteric nervous system; and (3) PGE2 and cAMP stimulate bicarbonate secretion independent of the enteric nervous system. Bicarbonates vasoactive intestinal peptide Homo sapiens