Title : Xenobiotic-modulated expression of hepatic glutathione S-transferase genes in primary rat hepatocyte culture.

Pub. Date : 1993 Jul 18

PMID : 8334163






2 Functional Relationships(s)
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1 Treatment of the hepatocyte cultures with phenobarbital (2 mM) or 3-methylcholanthene (5 microM) for 24, 48, or 72 h, beginning 24 h after plating, resulted in significant increases in glutathione S-transferase activity relative to control, with maximal increases of 158 and 164% measured at 72 h following phenobarbital or 3-methylcholanthrene treatment, respectively. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
2 Treatment of the hepatocyte cultures with phenobarbital (2 mM) or 3-methylcholanthene (5 microM) for 24, 48, or 72 h, beginning 24 h after plating, resulted in significant increases in glutathione S-transferase activity relative to control, with maximal increases of 158 and 164% measured at 72 h following phenobarbital or 3-methylcholanthrene treatment, respectively. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus