Pub. Date : 1993 Jun
PMID : 8333519
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amylin elicited a marked increase in plasma lactate, as previously reported, whereas glucagon did not alter plasma lactate. | Lactic Acid | islet amyloid polypeptide | Rattus norvegicus |
| 2 | In fed animals, glucagon elicited twice as much increase in plasma glucose as did amylin; amylin again elicited a marked lactate increase that was greater (increment 1.45 vs. 0.97 mM, P < 0.05) and more prolonged than in the fasted state, whereas glucagon was without effect on lactate levels. | Lactic Acid | islet amyloid polypeptide | Rattus norvegicus |
| 3 | In fed animals, glucagon elicited twice as much increase in plasma glucose as did amylin; amylin again elicited a marked lactate increase that was greater (increment 1.45 vs. 0.97 mM, P < 0.05) and more prolonged than in the fasted state, whereas glucagon was without effect on lactate levels. | Lactic Acid | islet amyloid polypeptide | Rattus norvegicus |
| 4 | These findings are consistent with glucagon"s known action to promote hyperglycemia from hepatic glycogenolysis and amylin"s demonstrated action to promote muscle glycogenolysis and increase lactate supply to the liver. | Lactic Acid | islet amyloid polypeptide | Rattus norvegicus |
| 5 | Thus increased lactate supply to the liver may account for amylin"s hyperglycemic effects. | Lactic Acid | islet amyloid polypeptide | Rattus norvegicus |