Title : Mapping the nucleotide-dependent conformational change of human N-ras p21 in solution by heteronuclear-edited proton-observed NMR methods.

Pub. Date : 1993 Jul 6

PMID : 8329399






2 Functional Relationships(s)
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1 Heteronuclear-edited proton-detected NMR methods are used to study the nucleotide-dependent conformational change between GDP- and GTP gamma S-bound forms of human N-ras p21. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
2 When GTP gamma S is substituted for GDP in cellular N-ras p21, the chemical shifts of resonances Asp-47, -126, -154, and Asn-172, as well as Gly-77 and -151, are not sensitive to nucleotide exchange, whereas Asp-30, -33, -38, -54, -57, -69, -92, -105, and -119 are affected. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens