Pub. Date : 1993 Jul
PMID : 8325995
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. | Histamine | interleukin 1 beta | Homo sapiens |
| 2 | We therefore investigated whether histamine modulated the synthesis of IL-1 beta. | Histamine | interleukin 1 beta | Homo sapiens |
| 3 | IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis. | Histamine | interleukin 1 beta | Homo sapiens |
| 4 | IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis. | Histamine | interleukin 1 beta | Homo sapiens |
| 5 | IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis. | Histamine | interleukin 1 beta | Homo sapiens |
| 6 | IL-1 alpha-induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10(-6)-10(-4) M. Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha-induced IL-1 beta synthesis. | Histamine | interleukin 1 beta | Homo sapiens |
| 7 | Histamine (10(-5) M) enhanced and sustained IL-1 beta mRNA levels in IL-1 alpha-stimulated PBMC. | Histamine | interleukin 1 beta | Homo sapiens |
| 8 | However, histamine reduced IL-1 beta mRNA half-life (2.4 vs 1.2 h), suggesting that histamine enhances IL-1 alpha-induced IL-1 beta synthesis at the level of transcriptional activation. | Histamine | interleukin 1 beta | Homo sapiens |
| 9 | However, histamine reduced IL-1 beta mRNA half-life (2.4 vs 1.2 h), suggesting that histamine enhances IL-1 alpha-induced IL-1 beta synthesis at the level of transcriptional activation. | Histamine | interleukin 1 beta | Homo sapiens |
| 10 | However, histamine reduced IL-1 beta mRNA half-life (2.4 vs 1.2 h), suggesting that histamine enhances IL-1 alpha-induced IL-1 beta synthesis at the level of transcriptional activation. | Histamine | interleukin 1 beta | Homo sapiens |
| 11 | However, histamine reduced IL-1 beta mRNA half-life (2.4 vs 1.2 h), suggesting that histamine enhances IL-1 alpha-induced IL-1 beta synthesis at the level of transcriptional activation. | Histamine | interleukin 1 beta | Homo sapiens |
| 12 | These results suggest that mast cells may sustain chronic inflammatory processes by upregulating self-induction of IL-1 through histamine release. | Histamine | interleukin 1 beta | Homo sapiens |