Title : Transcriptional regulation of cholesterol 7 alpha-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes.

Pub. Date : 1993 Jul 5

PMID : 8314765






3 Functional Relationships(s)
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1 Taurocholate and taurodeoxycholate (50 microM) repressed cholesterol 7 alpha-hydroxylase mRNA to 44 +/- 9 and 52 +/- 4%, respectively, of control values. Taurocholic Acid cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus
2 Cholesterol 7 alpha-hydroxylase specific activity was decreased by taurocholate or taurodeoxycholate (50 microM) to 26 +/- 9 and 56 +/- 3% of control, respectively; its transcriptional activity was repressed to 52 +/- 5% of control by taurocholate (50 microM). Taurocholic Acid cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus
3 Cholesterol 7 alpha-hydroxylase specific activity was decreased by taurocholate or taurodeoxycholate (50 microM) to 26 +/- 9 and 56 +/- 3% of control, respectively; its transcriptional activity was repressed to 52 +/- 5% of control by taurocholate (50 microM). Taurocholic Acid cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus