Title : Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes.

Pub. Date : 1994 Jan 20

PMID : 8304979






2 Functional Relationships(s)
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1 The efficacy of FBS AChE to detoxify several OPs was amplified by addition of bis-quaternary oximes, particularly 1-(2-hydroxyiminomethyl-1-pyridinium)-1-(4-carboxyaminopyridinium) -dimethyl ether hydrochloride (HI-6). asoxime chloride acetylcholinesterase Mus musculus
2 Addition of HI-6 to FBS AChE as a pretreatment drug amplified the efficacy of enzyme as a scavenger of nerve agents. asoxime chloride acetylcholinesterase Mus musculus