Title : Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline.

Pub. Date : 1993 Sep-Oct

PMID : 8292742






1 Functional Relationships(s)
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1 (4) The processing of the C-8 methyl group of furaylline is involved in inactivation as demonstrated by the observation of a deuterium isotope effect of approximately 2.0 on kinact and no effect on Ki when the C-8 methyl group protons of furafylline are replaced with deuterium atoms. furafylline homeobox C8 Homo sapiens