Pub. Date : 1993 Fall
PMID : 8292488
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cycloheximide prevents kainate-induced neuronal death and c-fos expression in adult rat brain. | Cycloheximide | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | Pretreatment with cycloheximide did not affect the transient induction of c-fos observed in numerous structures, but significantly reduced the prolonged expression of c-fos mRNA in kainate-vulnerable regions. | Cycloheximide | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | These results not only demonstrate that kainate-induced neurotoxicity and the prolonged expression of c-fos are both prevented by cycloheximide, but also strengthen idea that prolonged c-fos expression is a marker of neuronal death. | Cycloheximide | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |