Title : [Reduction of cytochrome p-450 content and activity by porphyrins after damage to the microsomal membrane by tetrachloromethane].

Pub. Date : 1993 May-Jun

PMID : 8291131






2 Functional Relationships(s)
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1 Natural porphyrin (hemin and its synthetic analogue--tetraphenylporphyrin with iron TPP-Fe3+) has been studied for its effect on activity of monooxygenase responses and cytochrome P-450 content against a background of introduction of four-chlorine carbon in the in vitro experiments. Hemin cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 The reducing effect of hemin and TPP-Fe3+ on cytochrome P-450 and dependent enzymes: N-demethylase, n-hydroxylase and benz(a)pyrene hydroxylase has been noticed; the synthetic analogue of heme was more efficient. Hemin cytochrome P450 family 4 subfamily F member 3 Homo sapiens