Pub. Date : 1994 Feb
PMID : 8289783
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In accordance with the suggestion that suppression of Oct-3/4 expression is a crucial step during embryogenesis, the Oct-3/4 upstream region contains multiple targets for RA-induced repression, probably to ensure accurate and prompt repression of Oct-3/4 expression. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 2 | Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 3 | Retinoic acid (RA)-induced differentiation of embryonal carcinoma (EC) cells is accompanied by decreased expression of the Oct-3/4 gene. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 4 | Retinoic acid (RA)-induced differentiation of embryonal carcinoma (EC) cells is accompanied by decreased expression of the Oct-3/4 gene. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 5 | Previous findings show that sequences in the Oct-3/4 enhancer region (designated RARE1) are targets for RA-mediated repression (H. Okazawa, K. Okamoto, F. Ishino, T. Ishino-Kaneko, S. Takeda, Y. Toyoda, M. Muramatsu, and H. Hamada, EMBO J. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 6 | We identified a novel cis element in the Oct-3/4 promoter harbors a putative Sp1 binding site and a RA-responsive element (designated RAREoct), which are juxtaposed to one another. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 7 | Using site-directed mutagenesis, we show that the RAREoct contributes to the transcriptional activation of Oct-3/4 promoter in P19 cells and, most interestingly, mediates the RA-induced repression in RA-differentiated EC cells. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 8 | In accordance with the suggestion that suppression of Oct-3/4 expression is a crucial step during embryogenesis, the Oct-3/4 upstream region contains multiple targets for RA-induced repression, probably to ensure accurate and prompt repression of Oct-3/4 expression. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |