Title : All-trans retinoic acid reverses phorbol ester resistance in a human myeloid leukemia cell line.

Pub. Date : 1994 Jan 15

PMID : 8286746






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Treatment of human HL-60 leukemic cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with activation of protein kinase C (PKC) and induction of monocytic differentiation. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
2 Treatment of human HL-60 leukemic cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with activation of protein kinase C (PKC) and induction of monocytic differentiation. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
3 In order to measure PKC expression associated with the reversal of TPA resistance by ATRA, we exposed HL-525 cells to ATRA and analyzed PKC-mRNA and protein levels. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
4 These findings are consistent with the hypothesis that ATRA reverses TPA resistance in HL-525 cells by enhancing the expression of PKC. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens