Title : Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase.

Pub. Date : 1993 Nov

PMID : 8285630






1 Functional Relationships(s)
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1 A comparative kinetic analysis of both the wild-type and the Ala-235 TEM-1 enzymes revealed little effect of this substitution of residue 235 on the turnover of penicillins but a greater effect on the turnover of cephalosporins. Cephalosporins hypothetical protein Escherichia coli