Pub. Date : 1993 Oct
PMID : 8280184
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exogenous glucocorticoids increase macrophage secretion of apo E by cholesterol-independent pathways. | Cholesterol | apolipoprotein E | Mus musculus |
| 2 | Macrophage apo E synthesis and secretion has been previously demonstrated to be regulated by intracellular free cholesterol levels and is decreased by cytokines and other inflammatory stimuli associated with macrophage activation. | Cholesterol | apolipoprotein E | Mus musculus |
| 3 | Therefore, while macrophage activation results in decreased apo E synthesis, macrophages exposed to anti-inflammatory agents including dexamethasone, TGF beta, or following cAMP elevation demonstrate increased apo E secretion by a cholesterol-independent mechanism. | Cholesterol | apolipoprotein E | Mus musculus |