Title : Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

Pub. Date : 1994 Jan 4

PMID : 8278410






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Exposure of these cells to tumor necrosis factor alpha resulted in internucleosomal cleavage of genomic DNA, yielding laddered patterns of oligonucleosomal fragments characteristic of apoptosis when resolved by agarose gel electrophoresis; similar responses were observed after exposure to exogenous sphingomyelinase or synthetic ceramides. Sepharose tumor necrosis factor Homo sapiens