Pub. Date : 1993 Dec 24
PMID : 8277505
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Replacement of the terminal carboxyl (COOH) of 14a with the bioisostere tetrazole in 16 (AT1 IC50 = 5 nM, AT2 IC50 = 130 nM) not only improved the AT1 potency by 4-fold but also resulted in a 50-fold increase in AT2 activity. | 1H-tetrazole | angiotensin II receptor, type 1a | Rattus norvegicus |
| 2 | Replacement of the terminal carboxyl (COOH) of 14a with the bioisostere tetrazole in 16 (AT1 IC50 = 5 nM, AT2 IC50 = 130 nM) not only improved the AT1 potency by 4-fold but also resulted in a 50-fold increase in AT2 activity. | 1H-tetrazole | angiotensin II receptor, type 1a | Rattus norvegicus |
| 3 | Tetrazole 34 was identified as the most potent (AT1 IC50 = 18 nM) AT1 receptor antagonist in a structurally distinct series of compounds derived from N-alkylation of dihydroindole 25. | 1H-tetrazole | angiotensin II receptor, type 1a | Rattus norvegicus |
| 4 | Tetrazole 34 was identified as the most potent (AT1 IC50 = 18 nM) AT1 receptor antagonist in a structurally distinct series of compounds derived from N-alkylation of dihydroindole 25. | 1H-tetrazole | angiotensin II receptor, type 1a | Rattus norvegicus |