Title : Inhibition of aldehyde dehydrogenases by methylene blue.

Pub. Date : 1993 Dec 14

PMID : 8274146






4 Functional Relationships(s)
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1 The effect of the redox dye methylene blue on the stability of NADH and on the activity of the enzyme aldehyde dehydrogenase (ALDH; EC 1.2.1.3) was examined. Methylene Blue aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
2 The effect of the redox dye methylene blue on the stability of NADH and on the activity of the enzyme aldehyde dehydrogenase (ALDH; EC 1.2.1.3) was examined. Methylene Blue aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
3 Methylene blue inhibited the human erythrocyte and leukocyte ALDHs and the rat liver mitochondrial low-Km ALDH in a concentration-dependent manner. Methylene Blue aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
4 The inhibition of ALDH and the resulting decrease in the redox effect on the NAD system bound to alcohol dehydrogenase (EC 1.1.1.1) could explain the protective effect of methylene blue against metabolic redox effects of ethanol. Methylene Blue aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus