Pub. Date : 1994 Jan
PMID : 8270251
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Biochemically, these mutations result in the ras gene product (p21) being constitutively activated in its GTP-bound form and insensitive to the hydrolytic action of the ras-specific GTPase-activating protein (ras GAP). | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |
| 2 | We hypothesized that, if tumor development is related to the p21 ras being in the active GTP-bound state, then a similar malignant phenotype may result from an inactivating mutation in the ras GAP gene in the region that interacts with ras p21 (so-called catalytic domain). | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |