Title : Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines.

Pub. Date : 1994 Jan

PMID : 8270251






2 Functional Relationships(s)
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1 Biochemically, these mutations result in the ras gene product (p21) being constitutively activated in its GTP-bound form and insensitive to the hydrolytic action of the ras-specific GTPase-activating protein (ras GAP). Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
2 We hypothesized that, if tumor development is related to the p21 ras being in the active GTP-bound state, then a similar malignant phenotype may result from an inactivating mutation in the ras GAP gene in the region that interacts with ras p21 (so-called catalytic domain). Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens