Pub. Date : 1993 Dec 3
PMID : 8267650
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Basal levels of c-myc were comparable for all three cell lines, but levels of c-jun and c-fos were elevated 2- to 4-fold in VP-16-resistant cell lines. | Etoposide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Exposure of both sensitive and resistant cells to 200 microM VP-16 for 5 hr resulted in no further changes in topoisomerase II mRNA levels but caused an additional 2- to 3-fold elevation in the level of c-jun mRNA, indicating that altered basal levels of this gene were not due to deregulation of this gene. | Etoposide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |