Title : TPA-enhanced invasion of Matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.

Pub. Date : 1993 Dec 2

PMID : 8253535






4 Functional Relationships(s)
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1 We previously found that the enhanced activity to invade Matrigel upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) was one of the major properties of a highly metastatic variant (L-10) of a human rectal adenocarcinoma cell line RCM-1. Tetradecanoylphorbol Acetate ribosomal protein L10 Homo sapiens
2 We previously found that the enhanced activity to invade Matrigel upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) was one of the major properties of a highly metastatic variant (L-10) of a human rectal adenocarcinoma cell line RCM-1. Tetradecanoylphorbol Acetate ribosomal protein L10 Homo sapiens
3 TPA markedly enhanced both haptotactic response to type-IV collagen and motility on tissue-culture glass substrate of L-10 cells in a dose-response manner quite similar to that of TPA-enhanced invasion of Matrigel. Tetradecanoylphorbol Acetate ribosomal protein L10 Homo sapiens
4 Thus, TPA treatment of L-10 cells enhanced invasion of Matrigel in association with augmentation of cell motility but did not enhance metalloproteinase activity. Tetradecanoylphorbol Acetate ribosomal protein L10 Homo sapiens