Title : Intracellular induction pathways for CD23 antigen and surface immunoglobulins in human tonsillar B cells: the roles of protein kinase C and tyrosine kinase-mediated signals.

Pub. Date : 1993 Nov

PMID : 8242759






5 Functional Relationships(s)
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1 The expression of CD23 on human tonsillar B cells is increased following treatment with interleukin 4 (IL-4) or 12-O-tetradecanoylphorbol 13-acetate (TPA), while that of surface immunoglobulins (sIgs) is increased by IL-4 but decreased by TPA. Tetradecanoylphorbol Acetate Fc epsilon receptor II Homo sapiens
2 The expression of CD23 on human tonsillar B cells is increased following treatment with interleukin 4 (IL-4) or 12-O-tetradecanoylphorbol 13-acetate (TPA), while that of surface immunoglobulins (sIgs) is increased by IL-4 but decreased by TPA. Tetradecanoylphorbol Acetate Fc epsilon receptor II Homo sapiens
3 The expression of CD23 on human tonsillar B cells is increased following treatment with interleukin 4 (IL-4) or 12-O-tetradecanoylphorbol 13-acetate (TPA), while that of surface immunoglobulins (sIgs) is increased by IL-4 but decreased by TPA. Tetradecanoylphorbol Acetate Fc epsilon receptor II Homo sapiens
4 In comparison, the up-regulation of CD23 by IL-4 and TPA was only partially blocked by these PKC inhibitors. Tetradecanoylphorbol Acetate Fc epsilon receptor II Homo sapiens
5 TK inhibitors, such as herbimycin A and genistein, decreased both the IL-4- and TPA-induced CD23 expression by 50-80%, but had modest effects on sIgs expression. Tetradecanoylphorbol Acetate Fc epsilon receptor II Homo sapiens