Title : Gene transfection and expression of the ovarian carcinoma marker folate binding protein on NIH/3T3 cells increases cell growth in vitro and in vivo.

Pub. Date : 1993 Dec 1

PMID : 8242637






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The FBP-transfected NIH/3T3 cells bound folic acid and internalized about 30-fold more folic acid than mock-transfected cells. Folic Acid far upstream element (FUSE) binding protein 1 Mus musculus
2 The FBP-transfected NIH/3T3 cells bound folic acid and internalized about 30-fold more folic acid than mock-transfected cells. Folic Acid far upstream element (FUSE) binding protein 1 Mus musculus
3 Growth analysis revealed that FBP-transfected NIH/3T3 cells like IGROV1 maintained their growth rate after 10 days of culture in medium containing physiological or low folate concentration, and tumors arising after transplanting FBP-tNIH/3T3 cells in nude mice were 3-fold heavier than those arising after transplantation of non-FBP-expressing NIH/3T3 cells. Folic Acid far upstream element (FUSE) binding protein 1 Mus musculus