Pub. Date : 1993 Dec 1
PMID : 8242617
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study identifies the specific human cytochrome P-450 (CYP) enzymes involved in hydroxylation leading to activation of the anticancer drug cyclophosphamide and its isomeric analogue, ifosphamide. | Cyclophosphamide | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | The present study identifies the specific human cytochrome P-450 (CYP) enzymes involved in hydroxylation leading to activation of the anticancer drug cyclophosphamide and its isomeric analogue, ifosphamide. | Cyclophosphamide | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | Furthermore, growth of cultured CYP2A6- and CYP2B6-expressing B-lymphoblastoid cells, but not of CYP-negative control cells, was inhibited by cyclophosphamide and ifosphamide as a consequence of prodrug activation to cytotoxic metabolites. | Cyclophosphamide | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |