Title : Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.

Pub. Date : 1993 Dec 1

PMID : 8242617






1 Functional Relationships(s)
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1 Overall, the present study establishes that liver microsomal CYP2B and CYP3A preferentially catalyze cyclophosphamide and ifosphamide 4-hydroxylation, respectively, suggesting that liver P-450-inducing agents targeted at these enzymes might be used in cancer patients to enhance drug activation and therapeutic efficacy. Cyclophosphamide cytochrome P450 family 3 subfamily A member 4 Homo sapiens