Title : Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.

Pub. Date : 1993 Dec 1

PMID : 8242617






2 Functional Relationships(s)
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1 In contrast, troleandomycin, a selective inhibitor of CYP3A3 and -3A4, and anti-CYP3A IgG substantially inhibited microsomal ifosphamide hydroxylation but had little or no effect on microsomal cyclophosphamide hydroxylation. Troleandomycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In contrast, troleandomycin, a selective inhibitor of CYP3A3 and -3A4, and anti-CYP3A IgG substantially inhibited microsomal ifosphamide hydroxylation but had little or no effect on microsomal cyclophosphamide hydroxylation. Troleandomycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens