Title : Tumor necrosis factor-alpha alters pulmonary vasoreactivity via neutrophil-derived oxidants.

Pub. Date : 1993 Nov

PMID : 8238533






2 Functional Relationships(s)
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1 The vascular effects of TNF were associated with 1) decreased lung effluent nitrite (NO2-, oxidation product of nitric oxide), 2) increased lung effluent superoxide (O2-), and 3) increased lung myeloperoxidase (MPO). Nitrogen Dioxide tumor necrosis factor Cavia porcellus
2 Superoxide dismutase (SOD, 10 U/ml) prevented 1) the effects of TNF on the hemodynamic responses to U-46619 and ACh and 2) the TNF-induced decrease in NO2-. Nitrogen Dioxide tumor necrosis factor Cavia porcellus