Pub. Date : 1993 Sep
PMID : 8230718
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effects of DbcAMP on tumor necrosis factor and interleukin-1 production in human monocytes]. | Bucladesine | tumor necrosis factor | Homo sapiens |
| 2 | To determine whether DbcAMP suppresses the production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) in human monocytes, we measured the levels of TNF and IL-1 in response to E. Coli lipopolysaccharide (40 micrograms.ml-1) in vitro. | Bucladesine | tumor necrosis factor | Homo sapiens |
| 3 | To determine whether DbcAMP suppresses the production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) in human monocytes, we measured the levels of TNF and IL-1 in response to E. Coli lipopolysaccharide (40 micrograms.ml-1) in vitro. | Bucladesine | tumor necrosis factor | Homo sapiens |
| 4 | We now show that DbcAMP suppressed dose-dependently the production of TNF in human monocytes, and DbcAMP totally suppressed it at the dose above 5 x 10(-4) M. However, DbcAMP did not suppress the production of IL-1 even at the dose of 5 x 10(-3) M in human monocytes. | Bucladesine | tumor necrosis factor | Homo sapiens |