Pub. Date : 1993 May
PMID : 8229818
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exposure to 20 mM lactate at the normal extracellular pH (pHo 7.4) for 10 min caused the pHi to fall rapidly by 0.24 pH units and cell shortening was reduced. | Lactic Acid | glucose-6-phosphate isomerase | Rattus norvegicus |
| 2 | During maintained exposure to lactate the pHi remained constant and cell shortening did not recover. | Lactic Acid | glucose-6-phosphate isomerase | Rattus norvegicus |
| 3 | Application of Na(+)-H+ exchanger inhibitors, amiloride or ethylisopropyl-amiloride (EIPA), abolished the recovery of pHi and shortening during maintained exposure to lactate at pHo 7.4 and caused an additional acidosis during maintained application of lactate at pHo 6.4. | Lactic Acid | glucose-6-phosphate isomerase | Rattus norvegicus |
| 4 | Application of Na(+)-H+ exchanger inhibitors, amiloride or ethylisopropyl-amiloride (EIPA), abolished the recovery of pHi and shortening during maintained exposure to lactate at pHo 7.4 and caused an additional acidosis during maintained application of lactate at pHo 6.4. | Lactic Acid | glucose-6-phosphate isomerase | Rattus norvegicus |
| 5 | In conclusion, the Na(+)-H+ exchanger is an important regulator of pHi during a lactate-induced intracellular acidosis. | Lactic Acid | glucose-6-phosphate isomerase | Rattus norvegicus |