Title : Vasopressin induces arachidonic acid release through pertussis toxin-sensitive GTP-binding protein in aortic smooth muscle cells: independence from phosphoinositide hydrolysis.

Pub. Date : 1993 Oct

PMID : 8227189






8 Functional Relationships(s)
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1 Vasopressin induces arachidonic acid release through pertussis toxin-sensitive GTP-binding protein in aortic smooth muscle cells: independence from phosphoinositide hydrolysis. Arachidonic Acid arginine vasopressin Rattus norvegicus
2 In the present study, we investigated the mechanism of vasopressin-induced arachidonic acid release in rat aortic smooth muscle cells. Arachidonic Acid arginine vasopressin Rattus norvegicus
3 Vasopressin stimulated both the release of arachidonic acid and the formation of IP3 dose dependently in the range between 10 pM and 1 microM. Arachidonic Acid arginine vasopressin Rattus norvegicus
4 The effect of vasopressin on arachidonic acid release was more potent than that on the formation of IP3. Arachidonic Acid arginine vasopressin Rattus norvegicus
5 Quinacrine, a phospholipase A2 inhibitor, significantly suppressed the vasopressin-induced arachidonic acid release but had little effect on the formation of inositol phosphates. Arachidonic Acid arginine vasopressin Rattus norvegicus
6 NaF, a GTP-binding protein activator, mimicked vasopressin by stimulating the arachidonic acid release. Arachidonic Acid arginine vasopressin Rattus norvegicus
7 The arachidonic acid release stimulated by a combination of vasopressin and NaF was not additive. Arachidonic Acid arginine vasopressin Rattus norvegicus
8 PTX partially but significantly suppressed the vasopressin-induced arachidonic acid release. Arachidonic Acid arginine vasopressin Rattus norvegicus