Title : Selective coupling of the T cell antigen receptor to phosphoinositide-derived diacylglycerol production in HPB-ALL T cells correlates with CD45-regulated p59fyn activity.

Pub. Date : 1993 Nov

PMID : 8223875






1 Functional Relationships(s)
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1 Our data suggest that in HPB-ALL cells the production of DAG following CD3-antigen cross-linking can be fully accounted for by the selective coupling of the TCR to breakdown of phosphatidylinositol-(4,5)-bisphosphate as the result of phospholipase C gamma 1 activation. Phosphatidylinositol 4,5-Diphosphate phospholipase C gamma 1 Homo sapiens