Title : Release of beta-hexosaminidase isoenzymes in cultured human fibroblasts.

Pub. Date : 1993 Jul 16

PMID : 8222275






1 Functional Relationships(s)
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1 Addition of NH4Cl even at 3 mM resulted in an increased release of total Hex, which was already noted within 24 h. We speculate that the increased concentration of plasma NH4+ in patients with liver disease interferes with the intracellular distribution pathway of the lysosomal enzymes and this could contribute to the increased content of lysosomal enzymes present in plasma from these patients. Ammonium Chloride O-GlcNAcase Homo sapiens